Watch Intently (two)pentobarbital will lessen the extent or influence of suvorexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Sturdy CYP3A4 inducers may possibly minimize suvorexant efficacy; if increased suvorexant dose demanded, do not exceed 20 mg/daypentobarbital raises effects of ifosfamide by influencing h