Watch Intently (two)pentobarbital will lessen the extent or influence of suvorexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Sturdy CYP3A4 inducers may possibly minimize suvorexant efficacy; if increased suvorexant dose demanded, do not exceed 20 mg/day
pentobarbital raises effects of ifosfamide by influencing hepatic enzyme CYP2B6 metabolism. Use Caution/Check. Coadministration of ifosfamide with CYP2B6 inducers might enhance metabolism of ifosfamide to its metabolite. Keep track of for increased effects/toxicities if merged with CYP2B6 inducers.
pentobarbital boosts toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. CYP3A4 inducers may possibly increase the metabolism of ifosfamide to its Energetic alkylating metabolites.
pentobarbital will minimize the extent or effect of pantoprazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Not known.
pentobarbital will minimize the extent or effect of isradipine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Mysterious.
Contraindicated (one)pentobarbital will minimize the level or effect of roflumilast by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will lower the extent or impact of estropipate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
The efficacy of hormonal contraceptives could be lessened. Use another method of contraception or possibly a backup technique when enzyme inducers are made use of with mixed hormonal contraceptives (CHCs), and continue backup contraception for 28 days just after discontinuing enzyme inducer to be sure contraceptive dependability.
pentobarbital will decrease the level or effect of efavirenz by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Mysterious.
pentobarbital decreases effects of hemin by pharmacodynamic antagonism. read more Use Warning/Watch. Drugs that improve delta-aminolevulinic acid synthetase may perhaps reduce hemin impact.
pentobarbital will lessen the level or outcome of vincristine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Mysterious.
Monitor Closely (one)pentobarbital will minimize the level or result of glecaprevir/pibrentasvir by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will lower the extent or impact of pioglitazone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unknown.
Withdrawal indications occur in infants born to moms who obtain barbiturates through the entire past trimester of pregnancy